I haven't tried Gtk or wxRuby, but FxRuby (based on FOX GUI) is quite 
good.  I find it to be easier to use than Ruby/Tk - for example, in 
FxRuby, scrollbars come for free, there's a TreeList that's as easy to 
use as any other language's tree view, and keyboard shortcuts (in a list 
box, press 'b' and the selection should jump to the first item beginning 
with 'b', that kind of thing) and mouse scroll wheels tend to work for 
free.

One issue with Ruby is that there's no full all-singing-all-dancing IDE 
which will do a lot of the hard work for you.  For example, C# guys 
(including me when I'm not writing installations or programming Ruby) 
get VS.NET or #Develop, both of which have form designers.  Since the 
form designer works out all the positioning, it makes it easier for the 
programmer.

However, since languages like Ruby don't have a full IDE (yet), you have 
to do more manually.  To alleviate this, languages such as Ruby tend to 
use GUI libraries that make this as simple as possible.  However, this 
does not result in GUIs that look particularly nice, and .

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